Generalized design of sequence–ensemble–function relationships for intrinsically disordered proteins

2025/10/06 by Ryan K. Krueger, Ryan Krueger, Michael P. Brenner +1 · 1 voice · 3 citations
Biochemistry, Genetics and Molecular Biology · #RNA Research and Splicing #Protein Structure and Dynamics #Heat shock proteins research

paper · doi:10.1038/s43588-025-00881-y

Cited by

• Toward a unified framework for determining conformational ensembles of disordered proteins
• Boltzmann-Expected Molecular Design with Decoupled Annealing Flows
• Computational design of intrinsically disordered proteins
• Accurate predictions of disordered protein ensembles with STARLING. [europepmc]

Discussions

• Happy to share our latest in @natcomputsci.nature.com led by (amazing) Ryan Krueger + colab w M. Brenner! We introduce a framework to directly design intrinsically disordered proteins (IDPs) from phy [bsky, 26 points, 2 comments]