Toward a unified framework for determining conformational ensembles of disordered proteins

2026/03/09 by Hamidreza Ghafouri, Pavel Kadeřávek, Ana M. Melo +29 · 1 voice
Biochemistry, Genetics and Molecular Biology · Materials Science · #Protein Structure and Dynamics #Bioinformatics and Genomic Networks #Enzyme Structure and Function

paper · doi:10.1038/s41592-026-03003-2

Citations

• Experimental Parameterization of an Energy Function for the Simulation of Unfolded Proteins
• Generalized design of sequence–ensemble–function relationships for intrinsically disordered proteins
• Scalable emulation of protein equilibrium ensembles with generative deep learning
• Design of intrinsically disordered protein variants with diverse structural properties
• A coarse‐grained model for disordered and multi‐domain proteins
• Principles of protein structural ensemble determination

Discussions

• Community perspective: Toward a unified framework for determining conformational ensembles of disordered proteins 🍝 with framework for experimental data acquisition, computational ensemble generati [bsky, 33 points, 0 comments]