2007/12/28 by Gašper Tkačik, William Bialek, Tkacik, Gasper +1
Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #FOS: Biological sciences #Gene Regulatory Network Analysis #Microbial Metabolic Engineering and Bioproduction #Molecular Networks (q-bio.MN)
paper · pdf · doi:10.48550/arxiv.0712.4385
openalex publication_date 2007/12/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
This review was written for the Encyclopedia of Complexity and System Science (Springer-Verlag, Berlin, 2008), and is intended as a guide to the growing literature which approaches the phenomena of cell biology from a more theoretical point of view. We begin with the building blocks of cellular networks, and proceed toward the different classes of models being explored, finally discussing the "design principles" which have been suggested for these systems. Although largely a dispassionate review, we do draw attention to areas where there seems to be general consensus on ideas that have not been tested very thoroughly and, more optimistically, to areas where we feel promising ideas deserve to be more fully explored.