Nitric oxide synthase inhibitors have antidepressant-like properties in mice

1999/05/01 by Andrew J Harkin, Andrew Harkin, Karen H Bruce +3 · 23 citations
Psychology · Medicine · Neuroscience · #Neuroendocrine regulation and behavior #Nitric Oxide and Endothelin Effects #Stress Responses and Cortisol

paper · doi:10.1016/s0014-2999(99)00191-0

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• Elevated level of nitric oxide mediates the anti-depressant effect of rubidium chloride in mice
• Forced swimming test in mice: a review of antidepressant activity
• 17α-ethinyl estradiol attenuates depressive-like behavior through GABAA receptor activation/nitrergic pathway blockade in ovariectomized mice
• Inhibition of neuronal nitric oxide synthase in the rat hippocampus induces antidepressant-like effects
• Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test
• Endogenous nitric oxide decreases hippocampal levels of serotonin and dopamine in vivo. [europepmc]
• Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memory. [europepmc]
• Low nNOS protein in the locus coeruleus in major depression. [europepmc]
• Nitric oxide production and monoamine oxidase activity in cancer patients during interferon-alpha therapy. [europepmc]
• Coexpression of serotonin and nitric oxide in the raphe complex: cortical versus subcortical circuit. [europepmc]
• Developmental nicotine exposure induced alterations in behavior and glutamate receptor function in hippocampus. [europepmc]
• Prenatal stress is a vulnerability factor for altered morphology and biological activity of microglia cells. [europepmc]
• Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation. [europepmc]
• Nitric Oxide Synthase Inhibitors as Antidepressants. [europepmc]
• The social defeat/overcrowding murine psychosocial stress model results in a pharmacologically reversible body weight gain but not depression - related behaviours. [europepmc]
• Neuronal nitric oxide synthase and affective disorders. [europepmc]
• Combined network pharmacology and virtual reverse pharmacology approaches for identification of potential targets to treat vascular dementia. [europepmc]
• GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior. [europepmc]
• Neuronal Nitric Oxide Synthase in Nucleus Accumbens Specifically Mediates Susceptibility to Social Defeat Stress through Cyclin-Dependent Kinase 5. [europepmc]
• Desipramine induces eryptosis in human erythrocytes, an effect blunted by nitric oxide donor sodium nitroprusside and N-acetyl-L-cysteine but enhanced by Calcium depletion. [europepmc]
• Unraveling the potential of vitamins C and D as adjuvants in depression treatment with escitalopram in an LPS animal model. [europepmc]
• Exploring the Roles of Vitamins C and D and Etifoxine in Combination with Citalopram in Depression/Anxiety Model: A Focus on ICAM-1, SIRT1 and Nitric Oxide. [europepmc]