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Mediation Analysis using Semi-parametric Shape-Restricted Regression with Applications

2023/10/13 by Qing Yin, Yin, Qing, Jong‐Hyeon Jeong +7
Medicine · #Applications (stat.AP) #Birth, Development, and Health #FOS: Computer and information sciences #Methodology (stat.ME) #Pregnancy and Medication Impact #Pregnancy and preeclampsia studies

paper · doi:10.48550/arxiv.2310.09185

openalex publication_date 2023/10/13 · openalex created_date 2023/10/17 · openalex updated_date 2026/07/28

Abstract

on the birth weight and a linear relationship between pesticide exposure and hCG, with both exposure-outcome and exposure-mediator models being linear in the confounding factors. Using the proposed methodology on a population-level prenatal screening program data, with hCG as the mediator, we discovered that, while the natural direct effects suggest a positive association between pesticide application and birth weight, the natural indirect effects were negative.

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