2015/10/20 by Veronika Weiß, Christian Argyo, Weiss, Veronika +15
Biochemistry, Genetics and Molecular Biology · Materials Science · Medicine · #Biological Physics (physics.bio-ph) #Dendrimers and Hyperbranched Polymers #FOS: Physical sciences #Peptidase Inhibition and Analysis #RNA Interference and Gene Delivery
paper · pdf · doi:10.48550/arxiv.1510.05930
openalex publication_date 2015/10/20 · openalex created_date 2022/10/03 · openalex updated_date 2026/07/28
Mesoporous silica nanoparticles (MSNs) attract increasing interest in the\nfield of gene and drug delivery due to their versatile features as a\nmultifunctional drug delivery platform. Here, we describe poly(amidoamine)\n(PAMAM) dendron-functionalized MSNs that fulfill key prerequisites for a\ncontrollable intracellular drug release. In addition to high loading capacity,\nthey offer 1) low cytotoxicity, showing no impact on the metabolism of\nendothelial cells, 2) specific cancer cell targeting due to receptor-mediated\ncell uptake, 3) a redox-driven cleavage of disulfide bridges allowing for\nstimuli-responsive cargo release, and most importantly, 4) a specific internal\ntrigger based on the high buffering capacity of PAMAM dendrons to provide\nendosomal escape.\n