2024/09/08 by Mahadi Hasan, Hasan, Mahadi, Camryn Grace Evett +3
Biochemistry, Genetics and Molecular Biology · Materials Science · Medicine · #Cancer Research and Treatment #Curcumin's Biomedical Applications #FOS: Biological sciences #Nanoparticle-Based Drug Delivery #Other Quantitative Biology (q-bio.OT)
paper · pdf · doi:10.48550/arxiv.2409.05222
openalex publication_date 2024/09/08 · openalex created_date 2024/10/22 · openalex updated_date 2026/07/28
Colorectal cancer (CRC) continues to be a significant global health burden, prompting the need for more effective and targeted therapeutic strategies. Nanoparticle-based drug delivery systems have emerged as a promising approach to address the limitations of conventional chemotherapy, offering enhanced specificity, reduced systemic toxicity, and improved therapeutic outcomes. This paper provides an in-depth review of the current advancements in the application of nanoparticles as vehicles for targeted drug delivery in CRC therapy. It covers a variety of nanoparticle types, including liposomes, polymeric nanoparticles, dendrimers, and mesoporous silica nanoparticles (MSNs), with a focus on their design, functionalization, and mechanisms of action. This review also examines the challenges associated with the clinical translation of these technologies and explores future directions, emphasizing the potential of nanoparticle-based systems to revolutionize CRC treatment.