2020/08/15 by Syed Mohammad Ashab Uddin, Uddin, Syed Mohammad Ashab, Sayeed Shafayet Chowdhury +3
Biochemistry, Genetics and Molecular Biology · Engineering · Medicine · #Advanced biosensing and bioanalysis techniques #Applied Physics (physics.app-ph) #FOS: Physical sciences #Instrumentation and Detectors (physics.ins-det) #Optics (physics.optics) #Plasmonic and Surface Plasmon Research #SARS-CoV-2 and COVID-19 Research
paper · pdf · doi:10.48550/arxiv.2008.10354
openalex publication_date 2020/08/15 · openalex created_date 2022/07/26 · openalex updated_date 2026/07/28
In this paper, we propose a surface plasmon resonance (SPR) structure based\non Kretschmann configuration incorporating layers of Silicon and BaTiO3 on\ntop of Ag for real-time detection of severe acute respiratory syndrome\ncoronavirus 2 (SARS-CoV-2) using thiol tethered DNA as a ligand. Extensive\nnumerical analysis based on transfer matrix theory as well as finite-difference\ntime-domain (FDTD) technique has been performed to characterize the sensor\nresponse considering sensitivity, full width at half maxima, and minimum\nreflection. About 7.6 times enhanced sensitivity has been obtained using the\nproposed architecture for SARS-CoV-2 detection, compared to the basic\nKretschmann configuration. Notably, the structure provides consistent\nenhancement over other competitive SPR structures for both angular and\nwavelength interrogations with a figure-of-merit of 692.28. Additionally, we\nrepeated simulations for various ligate-ligand pairs to assess the range of\napplicability and robust performance improvement has been observed. As a\nresult, the proposed sensor design provides a suitable configuration for highly\nsensitive, rapid, non-invasive biosensing which can be useful if adopted in\nexperimental sensing protocols.\n