NRF2 plays a protective role in diabetic retinopathy in mice

2013/11/02 by Zhenhua Xu, Yanhong Wei, Junsong Gong +16 · 26 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Genomics, phytochemicals, and oxidative stress #Retinal Diseases and Treatments #Endoplasmic Reticulum Stress and Disease

paper · pdf · doi:10.1007/s00125-013-3093-8

Citations

• An Integrated Approach to Diabetic Retinopathy Research
• Minocycline Reduces Proinflammatory Cytokine Expression, Microglial Activation, and Caspase-3 Activation in a Rodent Model of Diabetic Retinopathy

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• Molecular stress and neurovascular injury in the diabetic retina
• Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion. [europepmc]
• Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. [europepmc]
• Diabetic Retinopathy: Retina-Specific Methods for Maintenance of Diabetic Rodents and Evaluation of Vascular Histopathology and Molecular Abnormalities. [europepmc]
• Monomethyl fumarate promotes Nrf2-dependent neuroprotection in retinal ischemia-reperfusion. [europepmc]
• Anti-inflammatory effects of 4'-demethylnobiletin, a major metabolite of nobiletin. [europepmc]
• Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases. [europepmc]
• Exosomal MicroRNA-15a Transfer from the Pancreas Augments Diabetic Complications by Inducing Oxidative Stress. [europepmc]
• Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Diabetic Retinopathy. [europepmc]
• Involvement of Nrf2 in Ocular Diseases. [europepmc]
• Diabetic retinopathy: current understanding, mechanisms, and treatment strategies. [europepmc]
• The Role of Nrf2 in Cardiovascular Function and Disease. [europepmc]
• The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis. [europepmc]
• Astaxanthin Promotes Nrf2/ARE Signaling to Alleviate Renal Fibronectin and Collagen IV Accumulation in Diabetic Rats. [europepmc]
• The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1/Nrf2/ARE Signaling Pathway in Chronic Diseases. [europepmc]
• Astragaloside IV Exerts a Myocardial Protective Effect against Cardiac Hypertrophy in Rats, Partially via Activating the Nrf2/HO-1 Signaling Pathway. [europepmc]
• Neuroinflammation and oxidative stress act in concert to promote neurodegeneration in the diabetic retina and optic nerve: galectin-3 participation. [europepmc]
• The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation. [europepmc]
• Roles of Nrf2 in Protecting the Kidney from Oxidative Damage. [europepmc]
• Photoreceptor cells and RPE contribute to the development of diabetic retinopathy. [europepmc]
• Current understanding of the molecular and cellular pathology of diabetic retinopathy. [europepmc]
• Redox regulation of the insulin signalling pathway. [europepmc]
• Glutathione Metabolism and the Novel Role of Mitochondrial GSH in Retinal Degeneration. [europepmc]
• Risk Factors for Retinal Ganglion Cell Distress in Glaucoma and Neuroprotective Potential Intervention. [europepmc]
• High glucose concentrations induce oxidative stress by inhibiting Nrf2 expression in rat Müller retinal cells in vitro. [europepmc]
• Contribution of Müller Cells in the Diabetic Retinopathy Development: Focus on Oxidative Stress and Inflammation. [europepmc]