2022/04/29 by Alexandra-Maria Tăuţan, Elias Paolo Casula, Tautan, Alexandra-Maria +17
Neuroscience · #EEG and Brain-Computer Interfaces #FOS: Biological sciences #FOS: Computer and information sciences #FOS: Electrical engineering #Functional Brain Connectivity Studies #I.2.1 #Machine Learning (cs.LG) #Neurons and Cognition (q-bio.NC) #Signal Processing (eess.SP) #Transcranial Magnetic Stimulation Studies #electronic engineering #information engineering
paper · pdf · doi:10.48550/arxiv.2205.03241
openalex publication_date 2022/04/29 · openalex created_date 2022/05/11 · openalex updated_date 2026/07/28
Transcranial Magnetic Stimulation (TMS) combined with EEG recordings (TMS-EEG) has shown great potential in the study of the brain and in particular of Alzheimer's Disease (AD). In this study, we propose an automatic method of determining the duration of TMS induced perturbation of the EEG signal as a potential metric reflecting the brain's functional alterations. A preliminary study is conducted in patients with Alzheimer's disease (AD). Three metrics for characterizing the strength and duration of TMS evoked EEG (TEP) activity are proposed and their potential in identifying AD patients from healthy controls was investigated. A dataset of TMS-EEG recordings from 17 AD and 17 healthy controls (HC) was used in our analysis. A Random Forest classification algorithm was trained on the extracted TEP metrics and its performance is evaluated in a leave-one-subject-out cross-validation. The created model showed promising results in identifying AD patients from HC with an accuracy, sensitivity and specificity of 69.32%, 72.23% and 66.41%, respectively.