Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot

2003/10/15 by Johanna Laurikkala, Yoshiaki Kassai, Leila Pakkasjärvi +2 · 29 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #dental development and anomalies #Periodontal Regeneration and Treatments #Cancer-related gene regulation

paper · doi:10.1016/j.ydbio.2003.08.011

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• BMP signaling in the control of skin development and hair follicle growth
• Morphoregulation of teeth: modulating the number, size, shape and differentiation by tuning Bmp activity. [europepmc]
• Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. [europepmc]
• Phosphate: known and potential roles during development and regeneration of teeth and supporting structures. [europepmc]
• Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row. [europepmc]
• Characterization of wise protein and its molecular mechanism to interact with both Wnt and BMP signals. [europepmc]
• Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate. [europepmc]
• Genetic evidence that SOST inhibits WNT signaling in the limb. [europepmc]
• Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. [europepmc]
• SOSTDC1 differentially modulates Smad and beta-catenin activation and is down-regulated in breast cancer. [europepmc]
• Update on Wnt signaling in bone cell biology and bone disease. [europepmc]
• Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. [europepmc]
• Common developmental pathways link tooth shape to regeneration. [europepmc]
• Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner. [europepmc]
• Molecular patterning of the mammalian dentition. [europepmc]
• Common mechanisms in development and disease: BMP signaling in craniofacial development. [europepmc]
• Grainyhead-like 2 downstream targets act to suppress epithelial-to-mesenchymal transition during neural tube closure. [europepmc]
• TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation. [europepmc]
• Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans. [europepmc]
• The epidemiology of supernumerary teeth and the associated molecular mechanism. [europepmc]
• Multiple modes of Lrp4 function in modulation of Wnt/β-catenin signaling during tooth development. [europepmc]
• Molecular and cellular mechanisms of tooth development, homeostasis and repair. [europepmc]
• Genetics and signaling mechanisms of orofacial clefts. [europepmc]
• Intertwined Signaling Pathways Governing Tooth Development: A Give-and-Take Between Canonical Wnt and Shh. [europepmc]
• Tooth number abnormality: from bench to bedside. [europepmc]
• Sonic hedgehog signaling in craniofacial development. [europepmc]