The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development

2008/03/13 by Philip J. Gage, Min Qian, Dianqing Wu +1 · 26 citations
Biochemistry, Genetics and Molecular Biology · #Wnt/β-catenin signaling in development and cancer #Developmental Biology and Gene Regulation #Cancer-related gene regulation

paper · doi:10.1016/j.ydbio.2008.02.030

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• Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2
• FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate. [europepmc]
• Signaling "cross-talk" is integrated by transcription factors in the development of the anterior segment in the eye. [europepmc]
• Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2. [europepmc]
• Canonical Wnt/β-catenin signaling is required for maintenance but not activation of Pitx2 expression in neural crest during eye development. [europepmc]
• Pitx2 is an upstream activator of extraocular myogenesis and survival. [europepmc]
• Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models. [europepmc]
• c-Jun, at the crossroad of the signaling network. [europepmc]
• Forces generated by cell intercalation tow epidermal sheets in mammalian tissue morphogenesis. [europepmc]
• Interleukin-1β-induced Wnt5a enhances human corneal endothelial cell migration through regulation of Cdc42 and RhoA. [europepmc]
• The homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing cornea. [europepmc]
• Development of astrocytes in the vertebrate eye. [europepmc]
• Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouse. [europepmc]
• Wnt/β-catenin signaling modulates corneal epithelium stratification via inhibition of Bmp4 during mouse development. [europepmc]
• Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation. [europepmc]
• Foxc1 and Foxc2 in the Neural Crest Are Required for Ocular Anterior Segment Development. [europepmc]
• Species composition and environmental adaptation of indigenous Chinese cattle. [europepmc]
• DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation. [europepmc]
• Spatiotemporal dynamics of canonical Wnt signaling during embryonic eye development and posterior capsular opacification (PCO). [europepmc]
• Dkk2 promotes neural crest specification by activating Wnt/β-catenin signaling in a GSK3β independent manner. [europepmc]
• Regional Control of Hairless versus Hair-Bearing Skin by Dkk2. [europepmc]
• A cellular atlas of Pitx2- dependent cardiac development. [europepmc]
• Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model. [europepmc]
• Genetics Underlying the Interactions between Neural Crest Cells and Eye Development. [europepmc]
• The Ocular Neural Crest: Specification, Migration, and Then What? [europepmc]
• Towards a Better Vision of Retinoic Acid Signaling during Eye Development. [europepmc]