2014/07/24 by Ana Sofia Rufino Ferreira, Ferreira, Ana Sofia Rufino, Justin Hsia +7
Biochemistry, Genetics and Molecular Biology · Engineering · #Dynamical Systems (math.DS) #FOS: Electrical engineering #FOS: Mathematics #Gene Regulatory Network Analysis #Nanofabrication and Lithography Techniques #Systems and Control (eess.SY) #Viral Infectious Diseases and Gene Expression in Insects #electronic engineering #information engineering
paper · pdf · doi:10.48550/arxiv.1407.6426
openalex publication_date 2014/07/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
We propose a compartmental lateral inhibition system that generates contrasting patterns of gene expression between neighboring compartments. The system consists of a set of compartments interconnected by channels. Each compartment contains a colony of cells that produce diffusible molecules to be detected by the neighboring colony, and each cell is equipped with an inhibitory circuit that reduces its production when the detected signal is stronger. We develop a technique to analyze the steady-state patterns emerging from this lateral inhibition system and apply it to a specific implementation. The analysis shows that the proposed system indeed exhibits contrasting patterns within realistic parameter ranges.