Mathematical models for order of mutation problem in myeloproliferative neoplasm: non-additivity and non-commutativity

2023/02/16 by Yue Wang, Wang, Yue
Biochemistry, Genetics and Molecular Biology · Medicine · #Chronic Myeloid Leukemia Treatments #FOS: Biological sciences #Kruppel-like factors research #Molecular Networks (q-bio.MN) #Myeloproliferative Neoplasms: Diagnosis and Treatment #Populations and Evolution (q-bio.PE)

paper · pdf · doi:10.48550/arxiv.2302.07955

openalex publication_date 2023/02/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

In some patients of myeloproliferative neoplasm, two genetic mutations can be found: JAK2 V617F and TET2. When one mutation is present or not, the other mutation has different effects on regulating gene expressions. Besides, when both mutations are present, the order of occurrence might make a difference. In this paper, we build nonlinear ordinary differential equation models and Markov chain models to explain such phenomena.

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