Identification of the key DNA damage response genes for predicting immunotherapy and chemotherapy efficacy in lung adenocarcinoma based on bulk, single-cell RNA sequencing, and spatial transcriptomics

2024/02/05 by Shijie Sun, Kai Wang, Deyu Guo +4 · 25 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Adenocarcinoma #Biology #Cancer #Cancer Immunotherapy and Biomarkers #Cancer research #Chemotherapy #Cisplatin #DNA repair #Docetaxel #Drug resistance #Ferroptosis and cancer prognosis #Gene #Gene expression #Genetics #Immune system #Immunology #Immunotherapy #Lung cancer #Medicine #Oncology #Paclitaxel #Single-cell and spatial transcriptomics #Transcriptome

paper · doi:10.1016/j.compbiomed.2024.108078

published in Computers in Biology and Medicine 171, 108078 (Elsevier BV)

openalex publication_date 2024/02/05 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Citations

• Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
• Cancer treatment and survivorship statistics, 2022

Cited by

• Nucleotide metabolism-associated drug resistance gene NDUFA4L2 promotes colon cancer progression and 5-FU resistance. [europepmc]
• Integration of multi-omics profiling reveals an epigenetic-based molecular classification of lung adenocarcinoma: implications for drug sensitivity and immunotherapy response prediction. [europepmc]
• Integrated multi-omics profiling to establish an IGFBP-based prognostic score for pancreatic ductal adenocarcinoma: unraveling prognostic biomarkers, immune microenvironment crosstalk, and therapeutic implications. [europepmc]
• Targeting DNA Damage Response-Mediated Resistance in Non-Small Cell Lung Cancer: From Mechanistic Insights to Drug Development. [europepmc]
• Spatial transcriptomics uncovers immune-cell plasticity and dedifferentiation signatures in aggressive lung adenocarcinoma subtypes. [europepmc]
• Overcoming resistance to antibody-drug conjugates: from mechanistic insights to cutting-edge strategies. [europepmc]
• Harnessing AI to fuse phenotypic signatures for drug target identification: progress in computational modeling. [europepmc]
• Identification of Poor Prognosis-Associated Fibroblast Subpopulation Signature Genes Utilizing the Scissor Algorithm to Classify Colorectal Cancer Subtypes and Evaluate the Immune Landscape. [europepmc]
• Identification of a biologically coherent three gene immune signature predictive of immunotherapy benefit in gastric adenocarcinoma. [europepmc]
• A comprehensive review of mechanisms underlying resistance to immune checkpoint inhibitors. [europepmc]
• RNF216 as a Promising Biomarker for Prognosis, Immunotherapy, and Chemotherapy in LIHC: A Comprehensive Pan-Cancer Analysis and Experimental Validation. [europepmc]
• Unveiling the prognostic and immunotherapeutic role of Tregs in lung cancer using integrated analysis of single-cell and bulk RNA-sequencing. [europepmc]
• Multi-omics integration identifies ribosome biogenesis-active macrophage subpopulation and its key gene GNL2 in driving liver hepatocellular carcinoma progression and mechanisms. [europepmc]
• Molecular subtyping and prognostic model construction based on endosome-related genes in colorectal cancer. [europepmc]
• The role of growth heterogeneity in solid nodular non-small cell lung cancer in clinical practice: a narrative review. [europepmc]