Multi-color stimulated Raman scattering with a frame-to-frame\n wavelength-tunable fiber-based light source

2021/08/02 by Thomas Würthwein, Kristin Wallmeier, Würthwein, Thomas +11 · 1 citation
Biochemistry, Genetics and Molecular Biology · Engineering · Medicine · #Spectroscopy Techniques in Biomedical and Chemical Research #Photoacoustic and Ultrasonic Imaging #Optical Imaging and Spectroscopy Techniques

paper · pdf · doi:10.48550/arxiv.2108.00782

Abstract

We present multi-color imaging by stimulated Raman scattering (SRS) enabled\nby an ultrafast fiber-based light source with integrated amplitude modulation\nand frame-to-frame wavelength tuning. With a relative intensity noise level of\n-153.7 dBc/Hz at 20.25 MHz the light source is well suited for SRS imaging and\noutperforms other fiber-based light source concepts for SRS imaging. The light\nsource is tunable in under 5 ms per arbitrary wavelength step between 700\ncm^-1 and 3200 cm^-1, which allows for addressing Raman resonances from\nthe fingerprint to the CH-stretch region. Moreover, the compact and\nenvironmentally stable system is predestined for fast multi-color assessments\nof medical or rapidly evolving samples with high chemical specificity, paving\nthe way for diagnostics and sensing outside of specialized laser laboratories.\n

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