2024/03/27 by Klotz, Katrin, Drexler, Hans, Hartwig, Andrea +1
#2-(2-Methoxyethoxy)ethan-1-ol #2-(2-Methoxyethoxy)ethanol #571.95 Toxicology #571.95 Toxikologie #616.9803 Betriebs- und Arbeitsmedizin #616.9803 Industrial and occupational medicine #Arbeitsstoff #BAT value #BAT-Wert #Biologischer Arbeitsstoff-Toleranzwert #Biomonitoring #DEGME #Diethylene glycol methyl ether #Diethylene glycol monomethyl ether #Diethylenglykolmethylether #Diethylenglykolmonomethylether #Diglycol monomethyl ether #Diglykolmonomethylether #Gefahrstoff #Methoxyacetic acid #Methoxyessigsäure #Methyldiglycol #Methyldiglykol #Toxizität #Urin #biological tolerance value #biomonitoring #hazardous substance #occupational exposure #toxicity #urine
paper · doi:10.34865/bb11177e9_1or
In 2023, the German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) derived an occupational exposure limit value (maximum concentration at the workplace, MAK value) of 10 ml/m3 (50 mg/m3) for diethylene glycol monomethyl ether [111-77-3]. In this article, the data for diethylene glycol monomethyl ether are summarized and evaluated to derive a biological tolerance value (BAT value). The toxic effect of diethylene glycol monomethyl ether is related to the metabolite methoxyacetic acid and its metabolic precursor 2-methoxyethanol (ethylene glycol monomethyl ether). Therefore, those metabolites were considered for the evaluation of the BAT value. The BAT value for 2-methoxyethanol of 15 mg methoxyacetic acid/g creatinine was derived from the no observed adverse effect concentration (NOAEC) for haematotoxicity in humans. The NOAEC of testicular toxicity is in the same order of magnitude. Therefore, a BAT value of 15 mg methoxyacetic acid/g creatinine was derived for diethylene glycol monomethyl ether. Sampling time is at the end of the shift on the last day of the working week after at least 2 weeks of exposure.