2022/09/29 by Klotz, Katrin, Drexler, Hans, Hartwig, Andrea +1
#1 #1-Methoxy-2-(2-methoxyethoxy)ethan #1-Methoxy-2-(2-methoxyethoxy)ethane #1′-Oxybis(2-methoxyethane) #Arbeitsstoff #BAT value #BAT-Wert #Biologischer Arbeitsstoff-Toleranzwert #Biomonitoring #Bis(2-methoxyethyl) ether #Bis(2-methoxyethyl)ether #DEGDME #Diethylene glycol dimethyl ether #Diethylenglykoldimethylether #Diglyme #Dimethyldiglykol #Gefahrstoff #Methoxyacetic acid #Methoxyessigsäure #Toxizität #Urin #biological tolerance value #biomonitoring #hazardous substance #occupational exposure #toxicity #urine
paper · doi:10.34865/bb11196e7_3or
In 2019, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has derived a maximum workplace concentration (MAK value) of 1 ml/m 3 (5.56 mg/m 3 ) for diethylene glycol dimethyl ether (DEGDME) [ 111-96-6 ]. Data of the DEGDME metabolism in humans are not available. In rats, DEGDME is metabolised to methoxyethoxyacetic acid as well as methoxyacetic acid. The toxic effect of DEGDME is caused by the metabolite methoxyacetic acid and its metabolic precursor 2-methoxyethanol (ethylene glycol monomethyl ether). Therefore, those metabolites were considered for the derivation of a biological tolerance value (BAT value). The BAT value for 2-methoxyethanol of 15 mg methoxyacetic acid/g creatinine was based on the NOAEC (no observed adverse effect concentration) of the effects on the erythropoetic system (haematotoxicity) in humans. The NOAEC of testicular toxicity is in the same order of magnitude. The compliance with the BAT value of 15 mg methoxyacetic acid/g creatinine (that is, keeping the exposure levels below these values) is intended to protect the health of persons exposed to DEGDME. Therefore, a BAT value of 15 mg methoxyacetic acid/g creatinine was derived for DEGDME. Sampling time is at the end of shift, for long-term exposure after several previous shifts.