Cardiovascular Pharmacogenomics

2011/09/16 by Dan M. Roden, Julie A. Johnson, Stephen E. Kimmel +6 · 80 citations
Medicine · Pharmacology, Toxicology and Pharmaceutics · #Antiplatelet Therapy and Cardiovascular Diseases #Antiplatelet drug #Aspirin #Atrial fibrillation #Bioinformatics #Biology #Cardiology #Clopidogrel #Drug #Drug response #Genetics #Genotype #Heart failure #Intensive care medicine #Internal medicine #Medicine #Pharmacogenetics #Pharmacogenetics and Drug Metabolism #Pharmacogenomics #Pharmacology #Pharmacology and Obesity Treatment #Warfarin

paper · pdf · doi:10.1161/circresaha.110.230995

published in Circulation Research 109(7), 807-820 (Lippincott Williams & Wilkins)

openalex publication_date 2011/09/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Patients vary in their responses to drug therapy, and some of that variability is genetically determined. This review outlines general approaches used to identify genetic variation that influences drug response. Examples from specific therapeutic areas are presented, such as cholesterol management, arrhythmias, heart failure, hypertension, warfarin anticoagulation, and antiplatelet agents. A brief view of potential pathways to implementation is presented.

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• Pharmacogenetics in Cardiovascular Medicine. [europepmc]
• Opportunities and Challenges in Cardiovascular Pharmacogenomics: From Discovery to Implementation. [europepmc]
• Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy. [europepmc]
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• Biopsychosocial influence on shoulder pain: results from a randomized preclinical trial of exercise-induced muscle injury. [europepmc]
• Individualized Dose-Response to Statins Associated with Cardiovascular Disease Outcomes. [europepmc]

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