Cross-Reactive Chemical Sensor Arrays

2000/06/24 by Keith J. Albert, Nathan S. Lewis, Caroline L. Schauer +4 · 1,279 citations
Chemical Engineering · Chemistry · Engineering · #Advanced Chemical Sensor Technologies #Analytical Chemistry and Sensors #Art #Art history #Citation #Computer science #Electrochemical Analysis and Applications #Library science #Social media #World Wide Web

paper · doi:10.1021/cr980102w

published in Chemical Reviews 100(7), 2595-2626 (American Chemical Society)

openalex publication_date 2000/06/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/27

Abstract

Conventional approaches to chemical sensors have
\ntraditionally made use of a “lock-and-key” design,
\nwherein a specific receptor is synthesized in order to
\nstrongly and highly selectively bind the analyte of
\ninterest.1-6 A related approach involves exploiting a
\ngeneral physicochemical effect selectively toward a
\nsingle analyte, such as the use of the ionic effect in
\nthe construction of a pH electrode. In the first
\napproach, selectivity is achieved through recognition
\nof the analyte at the receptor site, and in the second,
\nselectivity is achieved through the transduction
\nprocess in which the method of detection dictates
\nwhich species are sensed. Such approaches are appropriate
\nwhen a specific target compound is to be
\nidentified in the presence of controlled backgrounds
\nand interferences. However, this type of approach
\nrequires the synthesis of a separate, highly selective
\nsensor for each analyte to be detected. In addition,
\nthis type of approach is not particularly useful for
\nanalyzing, classifying, or assigning human value
\njudgments to the composition of complex vapor
\nmixtures such as perfumes, beers, foods, mixtures of
\nsolvents, etc.

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