Supramolecular Stacking of Doxorubicin on Carbon Nanotubes for in vivo Cancer Therapy

2009/10/03 by Zhuang Liu, Liu, Zhuang, Alice C. Fan +17
Biochemistry, Genetics and Molecular Biology · Engineering · Materials Science · Physics and Astronomy · #Carbon Nanotubes in Composites #Graphene and Nanomaterials Applications #Nanoparticle-Based Drug Delivery #cond-mat.mtrl-sci #physics.med-ph #q-bio.TO

paper · pdf · doi:10.48550/arxiv.0910.0567

Angew. Chem. Int. Ed. 48, 7668-7672 (2009)

arxiv created 2009/10/03 · arxiv updated 2009/12/01

Abstract

Many therapeutic advantages such as prolonged circulation in the blood, increased tumor drug uptake, enhanced therapeutic efficacy, and markedly reduced toxic side effects are provided by a carbon nanotube based chemotherapeutic formulation. In this system, doxorubicin (DOX) is loaded onto the sidewalls of functionalized single-walled carbon nanotubes by supramolecular pi-pi stacking.

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