From haemostasis to immunity: The expanding frontiers of platelet biology

2026/07/25 by Xun Wu, Xun Grace Wu, Nicole Tomei +1
Medicine · Immunology and Microbiology · #Platelet Disorders and Treatments #Heparin-Induced Thrombocytopenia and Thrombosis #Neutrophil, Myeloperoxidase and Oxidative Mechanisms

paper · doi:10.1111/bjh.70710

Abstract

In a Nutshell, platelets are small and anucleate, yet remarkably versatile cells that bridge the gap between haemostasis, thrombosis, inflammation and adaptive immunity. This expanded functional spectrum uncovers new opportunities for understanding and treating immune-mediated thrombocytopenia and other haematological diseases.

Citations

• Platelet GPIb: sensing force and responding
• Thrombocytopenia Independently Leads to Changes in Monocyte Immune Function
• Anti–HPA-1a fetal-neonatal alloimmune thrombocytopenia: reframing diagnostics, pathophysiology, and management

Related

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• Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity
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• Thrombocytopenia Independently Leads to Changes in Monocyte Immune Function