2016/08/24 by Amani A. Alobaidi, Bo Sun, Alobaidi, Amani A. +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Engineering · Medicine · #3D Printing in Biomedical Research #Biology #Cancer #Cancer Cells and Metastasis #Cancer cell #Cancer metastasis #Cell #Cell Behavior (q-bio.CB) #Cell biology #Cellular Mechanics and Interactions #Chemistry #Dynamics (music) #Extracellular matrix #FOS: Biological sciences #Materials science #Matrix (chemical analysis) #Metastasis #Multicellular organism #Nanotechnology #Organoid #Physics #Tissues and Organs (q-bio.TO) #q-bio.CB #q-bio.TO
paper · pdf · doi:10.48550/arxiv.1608.06723
published in arXiv (Cornell University) (Cornell University)
arxiv created 2016/08/24 · openalex publication_date 2016/08/24 · arxiv updated 2016/08/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/08
Multicellular migration and pattern formation play important roles in developmental biology, cancer metastasis and wound healing. To understand the collective cell dynamics in three dimensional extracellular matrix (ECM), we have developed a simple and mechanical-based strategy, Diskoid In Geometrically Micropatterned ECM (DIGME). DIGME allows easy engineering of the shape of 3-D tissue organoid, the mesoscale ECM heterogeneity, and the fiber alignment of collagen-based ECM all at the same time. We have employed DIGME to study the collective cancer invasion and find that DIGME provides a powerful tool to probe three dimensional dynamics of tumor organoid in patterned microenvironment.