An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid

1982/09/01 by M.N. Perkins, T.W. Stone, Trevor W. Stone · 34 citations
Neuroscience · Psychology · #Tryptophan and brain disorders #Stress Responses and Cortisol #Neuroendocrine regulation and behavior

paper · doi:10.1016/0006-8993(82)91048-4

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• Characterization of ionotropic glutamate receptors in human lymphocytes
• Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies
• Decreased kynurenine pathway potentiate resilience to social defeat effect on cocaine reward
• Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders
• Kynurenine pathway metabolism and the microbiota-gut-brain axis
• The Astrocyte-Derived α7 Nicotinic Receptor Antagonist Kynurenic Acid Controls Extracellular Glutamate Levels in the Prefrontal Cortex
• Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation
• Individual and additive effects of childhood maltreatment and substance use disorder histories on baseline and stress-induced changes in peripheral stress biomarkers
• Negr1 deficiency alters glutamate signalling and kynurenine pathway in a mouse model of psychiatric disorders
• Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum. [europepmc]
• The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex. [europepmc]
• Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry. [europepmc]
• The concept of depression as a dysfunction of the immune system. [europepmc]
• Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. [europepmc]
• Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes. [europepmc]
• Kynurenines in the mammalian brain: when physiology meets pathology. [europepmc]
• Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges. [europepmc]
• Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid. [europepmc]
• The role of placental tryptophan catabolism. [europepmc]
• Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies. [europepmc]
• Elevated kynurenine pathway metabolism during neurodevelopment: Implications for brain and behavior. [europepmc]
• The kynurenine pathway and the brain: Challenges, controversies and promises. [europepmc]
• Stress, the Autonomic Nervous System, and the Immune-kynurenine Pathway in the Etiology of Depression. [europepmc]
• Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation. [europepmc]
• Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia. [europepmc]
• Kynurenic acid and cancer: facts and controversies. [europepmc]
• Does kynurenic acid act on nicotinic receptors? An assessment of the evidence. [europepmc]
• Inflammation-Induced Tryptophan Breakdown is Related With Anemia, Fatigue, and Depression in Cancer. [europepmc]
• IDO and Kynurenine Metabolites in Peripheral and CNS Disorders. [europepmc]
• Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes. [europepmc]
• Role of Kynurenine Pathway in Oxidative Stress during Neurodegenerative Disorders. [europepmc]
• Kynurenic acid in neurodegenerative disorders-unique neuroprotection or double-edged sword? [europepmc]
• Memory Enhancement with Kynurenic Acid and Its Mechanisms in Neurotransmission. [europepmc]
• Transporters buffer synaptically released glutamate on a submillisecond time scale. [europepmc]