DDX39B protects against sorafenib-induced ferroptosis by facilitating the splicing and cytoplasmic export of GPX4 pre-mRNA in hepatocellular carcinoma

2024/05/01 by Qin Li, Hang Yuan, Gang Zhao +15 · 16 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Apoptosis #Biochemistry #Biology #Cancer #Cancer cell #Cancer research #Cell #Cell biology #Chemistry #Downregulation and upregulation #Enzyme #Ferroptosis and cancer prognosis #GPX4 #Gene #Genetics #Glutathione #Hepatocellular carcinoma #Liver cancer #Programmed cell death #RNA Research and Splicing #RNA modifications and cancer #Sorafenib

paper · doi:10.1016/j.bcp.2024.116251

published in Biochemical Pharmacology 225, 116251 (Elsevier BV)

openalex publication_date 2024/05/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05

Citations

• Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

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• Piezobiomimetic delivery nanosystem converts cold tumors to hot by parallel PANoptosis/STING activation in hepatocellular carcinoma. [europepmc]