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Bi-Analyte Surface Enhanced Raman Scattering for unambiguous evidence of single molecule detection

2005/09/18 by E. C. Le Ru, Eric C. Le Ru, M. Meyer +6
Chemistry · Materials Science · Physics and Astronomy · #Chemical Physics (physics.chem-ph) #Electrochemical Analysis and Applications #FOS: Physical sciences #Gold and Silver Nanoparticles Synthesis and Applications #Quantum Dots Synthesis And Properties #physics.chem-ph

paper · pdf · doi:10.48550/arxiv.physics/0509153

6 pages, 4 figures

arxiv created 2005/09/18 · openalex publication_date 2005/09/18 · arxiv updated 2009/12/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/28

Abstract

A method is proposed to pin down an unambiguous proof for single molecule surface enhanced Raman spectroscopy (SERS). The simultaneous use of two analyte molecules enables a clear confirmation of the single (or few) molecule nature of the signals. This method eliminates most of the uncertainties associated with low dye concentrations in previous experiments. It further shows that single-molecule signals are very common in SERS, both in liquids and on dry substrates.

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