2017/12/08 by Sabra, Wael, Bommareddy, Rajesh Reddy, Maheshwari, Garima +2
#Chemie #Citrates #Citric Acid #Citric acid #Culture Media #Dual substrate #Fermentation #Gene Expression Profiling #Glucose #Glycerol #Glyoxylate cycle #Glyoxylates #Metabolic Flux Analysis #Oleaginous yeast #Oxygen #Pentose Phosphate Pathway #Pentose phosphate pathway #Yarrowia
paper · doi:10.15480/882.1496
Unlike the well-studied backer yeast where catabolite repression represents a burden for mixed substrate fermentation, Yarrowia lipolytica, an oleaginous yeast, is recognized for its potential to produce single cell oils and citric acid from different feedstocks. These versatilities of Y. lipolytica with regards to substrate utilization make it an attractive host for biorefinery application. However, to develop a commercial process for the production of citric acid by Y. lipolytica, it is necessary to better understand the primary metabolism and its regulation, especially for growth on mixed substrate.