2022/02/28 by Asbjørn Thode Reenberg, Tobias K. S. Ritschel, Reenberg, Asbjørn Thode +6
Computer Science · Decision Sciences · Engineering · Mathematics · #Advanced Control Systems Optimization #Simulation Techniques and Applications #Statistical Methods in Clinical Trials #cs.SY #eess.SY #math.OC
paper · pdf · doi:10.48550/arxiv.2202.13927
Accepted for publication in Proceedings of the 2022 American Control Conference (ACC), 6 pages, 8 figures
arxiv created 2022/02/28 · arxiv updated 2022/03/01
In this paper, we propose a virtual clinical trial for assessing the performance and identifying risks in closed-loop diabetes treatments. Virtual clinical trials enable fast and risk-free tests of many treatment variations for large populations of fictive patients (represented by mathematical models). We use closed-loop Monte Carlo simulation, implemented in high-performance software and hardware, to quantify the uncertainty in treatment performance as well as to compare the performance in different scenarios or of different closed-loop treatments. Our software can be used for testing a wide variety of control strategies ranging from heuristical approaches to nonlinear model predictive control. We present an example of a virtual clinical trial with one million patients over 52 weeks, and we use high-performance software and hardware to conduct the virtual trial in 1 h and 22 min.