2020/10/13 by Vasyl Alba, James E. Carthew, Alba, Vasyl +5
Biochemistry, Genetics and Molecular Biology · Mathematics · #Biological Physics (physics.bio-ph) #FOS: Biological sciences #FOS: Physical sciences #Genetic Mapping and Diversity in Plants and Animals #Genetics, Bioinformatics, and Biomedical Research #Morphological variations and asymmetry #Populations and Evolution (q-bio.PE) #Quantitative Methods (q-bio.QM) #Tissues and Organs (q-bio.TO)
paper · pdf · doi:10.48550/arxiv.2010.06656
openalex publication_date 2020/10/13 · openalex created_date 2022/07/25 · openalex updated_date 2026/07/28
Organismal phenotypes emerge from a complex set of genotypic interactions.\nWhile technological advances in sequencing provide a quantitative description\nof an organism's genotype, characterization of an organism's physical phenotype\nlags far behind. Here, we relate genotype to the complex and multi-dimensional\nphenotype of an anatomical structure using the Drosophila wing as a model\nsystem. We develop a mathematical approach that enables a robust description of\nbiologically salient phenotypic variation. Analysing natural phenotypic\nvariation, and variation generated by weak perturbations in genetic and\nenvironmental conditions during development, we observe a highly constrained\nset of wing phenotypes. In a striking ex-ample of dimensionality reduction, the\nnature of varieties produced by the Drosophila developmental pro-gram is\nconstrained to a single integrated mode of variation in the wing. Our strategy\ndemonstrates the emergent simplicity manifest in the genotype-to-phenotype map\nin the Drosophila wing and may represent a general approach for interrogating a\nvariety of genotype-phenotype relationships.\n