2018/06/13 by Hao Wang, Wang, Hao, Jiahui Wang +5
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Biological Physics (physics.bio-ph) #FOS: Biological sciences #FOS: Physical sciences #Ion channel regulation and function #Neurons and Cognition (q-bio.NC) #Neuroscience and Neuropharmacology Research #Photoreceptor and optogenetics research
paper · pdf · doi:10.48550/arxiv.1806.04710
openalex publication_date 2018/06/13 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
A quantized physical framework, called the five-anchor model, is developed for a general understanding of the working mechanism of ion channels. According to the hypotheses of this model, the following two basic physical principles are assigned to each anchor: the polarity change induced by an electron transition and the mutual repulsion and attraction induced by an electrostatic force. Consequently, many unique phenomena, such as fast and slow inactivation, the stochastic gating pattern and constant conductance of a single ion channel, the difference between electrical and optical stimulation (optogenetics), nerve conduction block and the generation of an action potential, become intrinsic features of this physical model. Moreover, this model also provides a foundation for the probability equation used to calculate the results of electrical stimulation in our previous C-P theory.