2024/04/22 by Belbachir, Y., El Farissi, H., ED Dahmouny, M. +5
paper · doi:10.48317/imist.prsm/morjchem-v12i3.47003
This study delves into the chemical composition of Laurus Nobilis (LN) essential oil, employing gas chromatography-mass spectrometry (GC-MS) and solid-phase microextraction (HS-SPME). The hydrodistillation process yielded essential oil at 0.5 % on a dry mass basis. Notably, the essential oil is characterized by a predominant presence of eucalyptol and linalool, collectively constituting 64.33 % of the total composition. Additionally, the research sheds light on the antioxidant properties of Laurus Nobilis supported by outcomes from DPPH analysis, b-carotene bleaching, and ABTS+ cation decolorization tests. The DPPH free radical scavenging assay demonstrated an IC50 of 0.86 ± 0.38 mg/ml. The b-carotene/linoleic acid bleach test indicated a IC50 of 2.58 ± 0.10 mg/ml. Comparatively, the ABTS assay revealed antioxidant activity slightly lower than that of ascorbic acid. Molecular docking studies identified caryophyllene, g-elemene, (-)-spathulenol, a-terpineol acetate, and a-terpineol as compounds with the highest anchoring scores on target proteins. These findings underscore the therapeutic significance in modulating target proteins. Keywords: GC-MS; HS-SPME; Molecular docking; Antioxidant activity; Antibacterial activity