Bone morphogenetic protein 8B (BMP8B) increases the glucose sensitivity of ventromedial hypothalamus (VMH) glucose-inhibited (GI) neurons in female mice.

2025/03/18

paper · doi:10.17912/micropub.biology.001496

Abstract

<p>In female, but not male, mice, bone morphogenetic protein (BMP) 8B affects energy homeostasis by inhibiting AMP activated protein kinase (AMPK) in the ventromedial hypothalamus (VMH). VMH glucose-inhibited (GI) neurons that express neuronal nitric oxide synthase (nNOS) increase blood glucose in an AMPK dependent fashion. We tested the hypothesis that <a>BMP8B</a> increases glucose inhibition on VMH nNOS-GI neurons. We found that more VMH nNOS neurons expressed the <a>BMP8B</a> receptor in females than males. Moreover, <a>BMP8B</a> blunted activation of VMH GI neurons in low glucose. Thus, VMH nNOS-GI neurons may mediate some of the metabolic effects of <a>BMP8B</a> in females.</p>

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