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Ultrashort pulse two-photon coherent control of a macroscopic phenomena: light-induced current from channelrhodopsin-2 in live brain cells

2019/07/17 by Cyrille Lavigne, Lavigne, Cyrille, Paul Brumer +1 · 2 citations
Neuroscience · Physics and Astronomy · #Photoreceptor and optogenetics research #Laser-Matter Interactions and Applications #Neural dynamics and brain function

paper · pdf · doi:10.48550/arxiv.1907.07741

Abstract

Coherent control is extended to macroscopic processes under continuous pulsed laser irradiation. Here, this approach is used to analyze the experimentally measured two-photon phase control of currents emanating from a living brain cells expressing channelrhodopsin-2, a light-gated ion channel. In particular, a mechanism is proposed that encompasses more than 15 orders magnitude in time, from the ultrafast dynamics of retinal in channelrhodopsin-2 to the slow dynamics of the neuron current. Implications for other photochemical processes are discussed.

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