Phosphorylation of Claudin-5 and Occludin by Rho Kinase in Brain Endothelial Cells

2008/01/11 by Masaru Yamamoto, Servio H. Ramirez, Shinji Sato +5 · 30 citations
Neuroscience · Medicine · #Barrier Structure and Function Studies #Neonatal and fetal brain pathology #Fetal and Pediatric Neurological Disorders

paper · pdf · doi:10.2353/ajpath.2008.070076

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• Blood–Brain Barrier Dysfunction in the Pathogenesis of Major Depressive Disorder
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• Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator. [europepmc]
• Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. [europepmc]
• Engaging neuroscience to advance translational research in brain barrier biology. [europepmc]
• Breaking down the barrier: the effects of HIV-1 on the blood-brain barrier. [europepmc]
• Role of reactive oxygen and nitrogen species in the vascular responses to inflammation. [europepmc]
• From mechanical force to RhoA activation. [europepmc]
• Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation. [europepmc]
• The tension mounts: stress fibers as force-generating mechanotransducers. [europepmc]
• Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke. [europepmc]
• Claudins and the modulation of tight junction permeability. [europepmc]
• Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization. [europepmc]
• ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation. [europepmc]
• Junctional proteins of the blood-brain barrier: New insights into function and dysfunction. [europepmc]
• Blood-brain barrier dysfunction and recovery after ischemic stroke. [europepmc]
• Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. [europepmc]
• Blood-Brain Barrier: From Physiology to Disease and Back. [europepmc]
• Claudin-5: gatekeeper of neurological function. [europepmc]
• Neuroinflammation During RNA Viral Infections. [europepmc]
• Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles. [europepmc]
• Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders. [europepmc]
• Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction. [europepmc]
• Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encephalopathy. [europepmc]
• Blood-Brain Barrier Dysfunction in CNS Disorders and Putative Therapeutic Targets: An Overview. [europepmc]