Heterozygous deletion of the autism-associated gene CHD8 impairs synaptic function through widespread changes in gene expression and chromatin compaction

2023/10/01 by Xi Shi, Congyi Lu, Alba Corman +8 · 11 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #CRISPR and Genetic Engineering #Genomics and Chromatin Dynamics #Autism Spectrum Disorder Research

paper · doi:10.1016/j.ajhg.2023.09.004

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• Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development. [europepmc]
• Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo. [europepmc]
• Large-scale discovery of neural enhancers for cis-regulation therapies [europepmc]