2025/06/29 by Hartwig, Andrea, MAK Commission
#571.95 Toxicology #571.95 Toxikologie #616.9803 Betriebs- und Arbeitsmedizin #616.9803 Industrial and occupational medicine #C6–C13 #Hydrocarbons #Kohlenwasserstoffe #Luft #MAK value #MAK-Wert #Naphtha (Erdöl) #Naphtha (petroleum) #Neurotoxizität #Siedebereich 65–230 °C #Spitzenbegrenzung #Stoddard Solvent IIC #air #aromatenfrei #aromatic-free Stoddard solvent IICWhite spirit #boiling points between 65 and 230 °C #central nervous system #dearomatized) (white spirit Type 3) #entaromatisiert (White Spirit Type 3) #hydrotreated heavy #maximale Arbeitsplatzkonzentration #maximum workplace concentration #mit Wasserstoff behandelte schwere #neurotoxicity #paraffinic and naphthenic #paraffinische und naphthenische #peak limitation #zentrales Nervensystem #„White Spirit“
paper · doi:10.34865/mb6474248yold10_2ad
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) summarized and re-evaluated the data for the derivation of the occupational exposure limit value (maximum concentration at the workplace, MAK value) for naphtha (petroleum), hydrotreated heavy [64742-48-9]. The critical effect is preclinical neurotoxicity. The results of a 13-week study with an isoparaffinic product in rats and a behavioural toxicity study in volunteers do not contradict the previous MAK value of 50 ml/m3. The assignment to Peak Limitation Category II with an excursion factor of 2 is retained. Additionally, there are no experimental data showing that juvenile animals are more sensitive to naphtha-induced neurotoxic effects than adults. Therefore, there is no evidence that would require changing the previous categorization from Pregnancy Risk Group D to Pregnancy Risk Group B (suspected prenatal toxicity).