2022/12/18 by Klotz, Katrin, Drexler, Hans, Hartwig, Andrea +1
#1 #1-Naphthol #2-Dihydroxy naphthalene #2-Dihydroxynaphthalin #2-Naphthol #Arbeitsstoff #Biomonitoring #EKA #Expositionsäquivalente für krebserzeugende Arbeitsstoffe #Gefahrstoff #N-Acetyl-S-(1-naphthyl)cystein #N-Acetyl-S-(1-naphthyl)cysteine #Naphthalene #Naphthalin #S-(1-Naphthyl)mercapturic acid #S-(1-Naphthyl)mercaptursäure #Toxizität #Urin #biomonitoring #exposure equivalents for carcinogenic substances #hazardous substance #occupational exposure #toxicity #urine
paper · doi:10.34865/bb9120e7_4ad
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has derived a biological reference value (BAR) for naphthalene [91-20-3] of 35 µg 1- plus 2-naphthol (after hydrolysis)/l urine in 2015. Since that time, further studies have been published, in which the relation between occupational exposure to naphthalene in air and biological exposure markers were determined. Based on the results of these studies, exposure equivalents for carcinogenic substances (EKA) for the urinary naphthalene metabolites 1,2-dihydroxynaphthalene (after hydrolysis), 1-naphthyl mercapturic acid and 1- plus 2-naphthol (after hydrolysis) were established. Sampling time is at the end of shift, for long-term exposures after several previous shifts.