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Brentuximab vedotin related bilateral Purtscher-like retinopathy unresponsive to pulse steroid therapy and intravitreal aflibercept injection

2017/12/15 by Ayhan, Ziya, Kaya, Sureyya Yigit, Ozcan, Mehmet Ali +1
Medicine · #610 Medical sciences #Brentixumab vedotin #Hodgkin’s lymphoma #Medicine #Purtscher-like retinopathy

paper · doi:10.3205/oc000080

Abstract

We describe a 36-year-old woman with a relapsing Hodgkin’s lymphoma who developed a severe bilateral sudden visual loss almost three weeks after the initiation of brentuximab therapy. Ancillary fundus tests yielded bilateral severe retinal arteriolar occlusion 360° and serous macular retinal detachment. No visual improvement could be achieved despite the pulse corticosteroid therapy and a single bilateral intravitreal aflibercept administration cessation of the brentuximab therapy. Unfortunately, she succumbed to respiratory failure almost six weeks after the diagnosis of Purtscher-like retinopathy.

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