Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

2009/04/27 by Thomas G. Beach, Charles H. Adler, Lih‐Fen Lue +18 · 40 citations
Medicine · Neuroscience · #Parkinson's Disease Mechanisms and Treatments #Genetic Neurodegenerative Diseases #Ginkgo biloba and Cashew Applications

paper · doi:10.1007/s00401-009-0538-8

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• Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve. [europepmc]
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• Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction. [europepmc]