2024/03/27 by Michaelsen, Sandra, Bartsch, Rüdiger, Brinkmann, Britta +4
#1 #1-Hydroxy-2-methoxyethane #1-Methoxy-2-hydroxyethan #1`-Oxybis(2-methoxy ethane) #2-(2-Methoxyethoxy)ethan-1-ol #2-(2-Methoxyethoxy)ethanol #2-Methoxyethanol #2-Methoxyethanolacetat #2-Methoxyethyl acetate #2-Methoxyethyl ether #2-Methoxyethylacetat #571.95 Toxicology #571.95 Toxikologie #616.9803 Betriebs- und Arbeitsmedizin #616.9803 Industrial and occupational medicine #Acetic acid (2-methoxyethyl)-ester #Acetic acid 2-methoxy-ethyl ester #Arbeitsstoff #BAT value #BAT-Wert #Biologischer Arbeitsstoff-Toleranzwert #Biomonitoring #Bis(2-methoxyethyl)ether #DEGDME #DEGME #Diethylene glycol dimethyl ether #Diethylene glycol methyl ether #Diethylene glycol monomethyl ether #Diethylenglykoldimethylether #Diethylenglykolmethylether #Diethylenglykolmonomethylether #Diglycol monomethyl ether #Diglykolmonomethylether #Diglyme #Dimethyldiglykol #EGME #EGMEA #Entwicklungstoxizität #Essigsäure-2-methoxyethylester #Ethandiolmonomethylether #Ethanol-2-methoxyacetate #Ethylene glycol methyl acetate #Ethylene glycol methyl ether #Ethylene glycol methyl ether acetate #Ethylene glycol monomethyl ether #Ethylene glycol monomethyl ether acetate #Ethylenglykolmonomethylether #Ethylenglykolmonomethyletheracetat #Gefahrstoff #Glycol monomethyl ether acetate #Glycolmethyl ether #Glykolmonomethylether #Glykolmonomethyletheracetat #Methoxyacetic acid #Methoxyessigsäure #Methoxyhydroxyethane #Methyl oxitol #Methylcellosolve #Methylcellosolveacetat #Methyldiglycol #Methyldiglykol #Methyldiglyme #Methylglycol acetate #Methylglykol #Methylglykolacetat #Monomethyl ether acetate #Monomethyl ether of ethylene glycol #Schwangerschaftsgruppe #Toxizität #Urin #biological tolerance value #biomonitoring #developmental toxicity #fruchtschädigende Wirkung #hazardous substance #occupational exposure #pregnancy risk group #prenatal toxicity #toxicity #urine
paper · doi:10.34865/bb62545d9_1ad
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) summarized and evaluated the data for prenatal toxicity and derived a methoxyacetic acid concentration in urine at which damage to the embryo or foetus is unlikely (“prerequisite for Pregnancy Risk Group C”) for 2-methoxyethanol [109-86-4], 2-methoxyethyl acetate [110-49-6], methoxyacetic acid [625-45-6], diethylene glycol dimethyl ether [111-96-6], and diethylene glycol monomethyl ether [111-77-3]. These substances are classified in Pregnancy Risk Group B because adhering to the biological tolerance value (BAT value) of 15 mg methoxyacetic acid/g creatinine cannot exclude a risk to the developing foetus. This classification was based on embryo-/foetotoxic and teratogenic effects in rats, mice, rabbits and monkeys. The effects are caused by methoxyacetic acid, the metabolite of all substances. From the lowest NOAEC (no observed adverse effect concentration) for developmental toxicity in rabbits of 3 ml 2-methoxyethanol/m3, a concentration of 0.15 ml 2-methoxyethanol/m3 at the workplace was derived for which damage to the embryo or foetus is unlikely. This external concentration corresponds to a urine concentration of 2.5 mg methoxyacetic acid/g creatinine. Therefore, an internal exposure not higher than this concentration would be the prerequisite for an assignment to Pregnancy Risk Group C.