2020/07/28 by Zheyu Zhu, Zhu, Zheyu, Yuzhe Lu +9
Computer Science · Medicine · #AI in cancer detection #Colorectal Cancer Screening and Detection #Computer Vision and Pattern Recognition (cs.CV) #FOS: Computer and information sciences #FOS: Electrical engineering #Image and Video Processing (eess.IV) #Medical Image Segmentation Techniques #electronic engineering #information engineering
paper · pdf · doi:10.48550/arxiv.2007.13952
openalex publication_date 2020/07/28 · openalex created_date 2020/08/03 · openalex updated_date 2026/07/28
Considerable morphological phenotyping studies in nephrology have emerged in the past few years, aiming to discover hidden regularities between clinical and imaging phenotypes. Such studies have been largely enabled by deep learning based image analysis to extract sparsely located targeting objects (e.g., glomeruli) on high-resolution whole slide images (WSI). However, such methods need to be trained using labor-intensive high-quality annotations, ideally labeled by pathologists. Inspired by the recent "human-in-the-loop" strategy, we developed EasierPath, an open-source tool to integrate human physicians and deep learning algorithms for efficient large-scale pathological image quantification as a loop. Using EasierPath, physicians are able to (1) optimize the recall and precision of deep learning object detection outcomes adaptively, (2) seamlessly support deep learning outcomes refining using either our EasierPath or prevalent ImageScope software without changing physician's user habit, and (3) manage and phenotype each object with user-defined classes. As a user case of EasierPath, we present the procedure of curating large-scale glomeruli in an efficient human-in-the-loop fashion (with two loops). From the experiments, the EasierPath saved 57 % of the annotation efforts to curate 8,833 glomeruli during the second loop. Meanwhile, the average precision of glomerular detection was leveraged from 0.504 to 0.620. The EasierPath software has been released as open-source to enable the large-scale glomerular prototyping. The code can be found in https://github.com/yuankaihuo/EasierPath