Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

2017/09/11 by Egle Cekanaviciute, Bryan B. Yoo, Tessel F. Runia +19 · 35 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Gut microbiota and health #Clostridium difficile and Clostridium perfringens research #Dermatology and Skin Diseases

paper · pdf · doi:10.1073/pnas.1711235114

Abstract

Significance We have experimentally investigated the immunoregulatory effects of human gut microbiota in multiple sclerosis (MS). We have identified specific bacteria that are associated with MS and demonstrated that these bacteria regulate T lymphocyte-mediated adaptive immune responses and contribute to the proinflammatory environment in vitro and in vivo. Thus, our results expand the knowledge of the microbial regulation of immunity and may provide a basis for the development of microbiome-based therapeutics in autoimmune diseases.

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