2016/04/28 by Sonia M. Razavi, Gerardo Callegari, Razavi, Sonia M. +5
Biochemistry, Genetics and Molecular Biology · Engineering · Pharmacology, Toxicology and Pharmaceutics · #Drug Solubulity and Delivery Systems #FOS: Physical sciences #Injection Molding Process and Properties #Materials Science (cond-mat.mtrl-sci) #Protein purification and stability #Soft Condensed Matter (cond-mat.soft)
paper · pdf · doi:10.48550/arxiv.1604.08438
openalex publication_date 2016/04/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
An ultrasound measurement system was employed as a non-destructive method to\nevaluate its reliability in predicting the tensile strength of tablets and\ninvestigate the benefits of incorporating it in a continuous line,\nmanufacturing solid dosage forms. Tablets containing lactose, acetaminophen,\nand magnesium stearate were manufactured continuously and in batches. The\neffect of two processing parameters, compaction force and level of shear strain\nwere examined. Young's modulus and tensile strength of tablets were obtained by\nultrasound and diametrical mechanical testing, respectively. It was found that\nas the blend was exposed to increasing levels of shear strain, the speed of\nsound in the tablets decreased and the tablets became both softer and\nmechanically weaker. Moreover, the results indicate that two separate tablet\nmaterial properties (e.g., relative density and Young's modulus) are necessary\nin order to predict tensile strength. A strategy for hardness prediction is\nproposed that uses the existing models for Young's modulus and tensile strength\nof porous materials. Ultrasound testing was found to be very sensitive in\ndifferentiating tablets with similar formulation but produced under different\nprocessing conditions (e.g., different level of shear strain), thus, providing\na fast, and non-destructive method for hardness prediction that could be\nincorporated to a continuous manufacturing process.\n