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Scope review of the effect of exercise on the intervention of bone and joint symptoms associated with aromatase inhibitors in breast cancer

2025/05/12 by , Miao
#Medicine and Health Sciences

paper · doi:10.17605/osf.io/xceht

Abstract

Objective A scoping review of the effectiveness of exercise as an intervention in breast cancer patients treated with aromatase inhibitors to identify the modalities and application effects of exercise for the clinical prevention and relief of aromatase inhibitor-related osteoarticular symptom. Methods A systematic search was conducted for relevant studies from China Knowledge, Wanfang, Wipro, China Biomedical Literature Database, PubMed, Embase. The search period covered from the establishment of the databases to March 31, 2025. The included literature was summarised and analysed. Results A total of 21 article were included, and the main forms of exercise in breast cancer aromatase inhibitor-associated bone and joint symptoms included aerobic exercise, resistance exercise, traditional Chinese exercise and multi-modal combined exercise. Conclusions Exercise is feasible, effective and safe for breast cancer aromatase inhibitor-associated osteoarthritic symptoms. In the future, it is still necessary to determine the optimal form and duration of exercise in order to maximise the bone health of breast cancer patients and to improve treatment outcomes and quality of life.

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