2008/10/30 by Craig L. Maynard, Casey T. Weaver · 2 citations
Immunology and Microbiology · #Biology #Cell biology #Cytokine #Effector #Homeostasis #IL-2 receptor #IL-33, ST2, and ILC Pathways #Immune Cell Function and Interaction #Immune system #Immunology #Inflammation #Interleukin 10 #Regulatory T cell #T cell #T-cell and B-cell Immunology
paper · doi:10.1111/j.1600-065x.2008.00711.x
openalex publication_date 2008/10/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Recent progress in our understanding of mechanisms by which the immunosuppressive cytokine interleukin-10 (IL-10) participates in an ever-increasing diversity of T-cell lineages to maintain immune homeostasis has broadened the framework for defining regulatory and effector T cells and has blurred the lines between them. In this review, we highlight established and emerging roles for IL-10 produced by distinct CD4(+) T-cell lineages that underlie its non-redundant role in curbing immune responses to the intestinal microbiota at steady state and its role to limit T-cell-driven inflammation in responses to pathogens.