2022/07/01 by Burroughs, Nigel J., McAinsh, Andrew D.
#92B05 #Biological Physics (physics.bio-ph) #FOS: Physical sciences
paper · doi:10.48550/arxiv.2207.00481
During cell division paired (sister) chromosomes are observed to perform approximate saw-tooth oscillations across the cell mid-plane. Experimental data suggests that these oscillations are regulated through intersister tension. We propose a time dependent tension threshold model that exhibits three stable periodic solutions and the phase diagram can be generated semi-analytically. Incorporation of diffusive noise reproduces realistic oscillations, with realistic periods, amplitudes and reproducing the observation that either sister of the pair can switch direction first.