2024/11/11 by Elizabeth Richardson, Riah Patterson, Samantha Meltzer-Brody +5 · 35 citations
Medicine · Psychology · #Biology #Depression (economics) #Developmental psychology #Identity, Memory, and Therapy #Major depressive disorder #Maternal Mental Health During Pregnancy and Postpartum #Medicine #Mood #Postpartum depression #Pregnancy #Psychiatry #Psychology #Psychotherapist #Transformative learning #Treatment of Major Depression
paper · doi:10.1146/annurev-med-050423-095712
published in Annual Review of Medicine 76(1), 81-93 (Annual Reviews)
openalex publication_date 2024/11/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/03
Depressive disorders present an enormous global public health burden. A notable treatment gap exists between the prevalence of depression and our ability to provide rapid-acting, effective treatment that achieves remission. Brexanolone and zuranolone, the first US Food and Drug Administration-approved drugs for postpartum depression, signify a critical advancement in addressing the unmet needs of a vulnerable patient population. Psilocybin shows promise for treatment-resistant depression and for those who have struggled to find relief with existing treatments. This review discusses transformative therapies that represent significant advancements in postpartum depression, major depressive disorder, and treatment-resistant depression.