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Postpartum Depression: Pathophysiology, Treatment, and Emerging Therapeutics

2019/01/27 by Donna E. Stewart, Simone N. Vigod · 447 citations
Medicine · Psychology · #Anxiety #Breastfeeding #Child and Adolescent Psychosocial and Emotional Development #Childbirth #Depression (economics) #Infant Development and Preterm Care #Intensive care medicine #Maternal Mental Health During Pregnancy and Postpartum #Medicine #Mood #Pediatrics #Postpartum depression #Pregnancy #Psychiatry

paper · doi:10.1146/annurev-med-041217-011106

published in Annual Review of Medicine 70(1), 183-196 (Annual Reviews)

openalex publication_date 2019/01/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05

Abstract

Postpartum depression (PPD) is common, disabling, and treatable. The strongest risk factor is a history of mood or anxiety disorder, especially having active symptoms during pregnancy. As PPD is one of the most common complications of childbirth, it is vital to identify best treatments for optimal maternal, infant, and family outcomes. New understanding of PPD pathophysiology and emerging therapeutics offer the potential for new ways to add to current medications, somatic treatments, and evidence-based psychotherapy. The benefits and potential harms of treatment, including during breastfeeding, are presented.

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