MUTAGENESIS BY APURINIC/APYRIMIDINIC SITES

1986/12/01 by Lawrence A. Loeb, Bradley D. Preston · 6 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #DNA and Nucleic Acid Chemistry #Analytical Chemistry and Chromatography #Carcinogens and Genotoxicity Assessment

paper · doi:10.1146/annurev.ge.20.120186.001221

Abstract

INTRODUCTION . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . 201 S OURCES OF AP SITES . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 202 Spontaneous DepurinationlDepyrimidination . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 202 Chemically Induced DepurinationlDepyrimidination . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 203 DepurinationlDepyrimidination by DNA Glycosylases . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . 207 REPAIR OF AP SITES . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 209 MUTAGENESIS BY AP SITES . . . .... . . . . . . . . .. . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 210 Misincorporation by DNA Polymerases in vitro . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 210 Mutagenesis in E. coli... . . . . . . . . . ..... . . . . . . . . . 2 1 2 Mutagenesis in Animal Cells . . . .. . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1 3 A P Sites a s Intermediates in Spontaneous Mutagenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 214 AP Sites as Intermediates in Chemical Mutagenesis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 216 MOLECULAR MECHANISMS FOR MUTAGENESIS BY AP S ITES . . . . . . . . .. . . . . . . . . . 219

Cited by

• Mechanisms of Chromium Carcinogenicity and Toxicity
• Cytochrome P450 1B1–Mediated Estrogen Metabolism Results in Estrogen-Deoxyribonucleoside Adduct Formation
• Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer
• DNA Sequence Analysis of Spontaneous Mutagenesis in Saccharomyces cerevisiae
• p53 Mutations in Human Cancers
• Instability and decay of the primary structure of DNA

Related

• Site-Specific Self-Catalyzed DNA Depurination: A Biological Mechanism That Leads to Mutations and Creates Sequence Diversity
• Natural site-directed mutagenesis might exist in eukaryotic cells
• SPONTANEOUS MUTATORS IN BACTERIA: Insights into Pathways of Mutagenesis and Repair
• Polycyclic Aromatic Hydrocarbon (PAH) o-Quinones Produced by the Aldo-Keto-Reductases (AKRs) Generate Abasic Sites, Oxidized Pyrimidines, and 8-Oxo-dGuo via Reactive Oxygen Species
• Generation of single-nucleotide repair patches following excision of uracil residues from DNA.