2008/01/01 by Constantin C. Coussios, Constantin Coussios, Ronald A. Roy · 522 citations
Engineering · Materials Science · Medicine · #Acoustics #Biomedical engineering #Cavitation #Computer science #Context (archaeology) #Drug delivery #Geology #High-intensity focused ultrasound #Materials science #Medical physics #Medicine #Microfluidic and Bio-sensing Technologies #Nanotechnology #Physics #Therapeutic ultrasound #Ultrasound #Ultrasound and Cavitation Phenomena #Ultrasound and Hyperthermia Applications
paper · doi:10.1146/annurev.fluid.40.111406.102116
published in Annual Review of Fluid Mechanics 40(1), 395-420 (Annual Reviews)
openalex publication_date 2008/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Biomedical acoustics is rapidly evolving from a diagnostic modality into a therapeutic tool, and acoustic cavitation is often the common denominator in a wide range of new therapeutic applications. High-intensity focused ultrasound (HIFU) waves generated outside the body can be used to deposit heat deep within the body. Through a quantitative analysis of heat deposition by ultrasound, it is shown that inertial cavitation can help address some of the major challenges of HIFU therapy by providing a means of enhancing and monitoring treatment noninvasively. In the context of drug delivery, both inertial and stable cavitation play roles in enhancing drug activity and uptake. In particular, shape oscillations arising during stable cavitation provide an effective micropumping mechanism for enhanced mass transport across inaccessible interfaces.